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Codeine is one of the three main alkaloids extracted from the opium poppy, Papaver somniferum and although pure codeine can be extracted as a natural source, most codeine medications in United States and Canada are in the semi-synthetic forms of codeine sulfate or codeine phosphate which are processed from morphine. Like morphine, heroin, and other opioid drugs, codeine can produce a tolerance after several uses and the user will require more codeine to achieve the desired effects.
Codeine Uses
Codeine can be prescribed alone or in varying combinations with other drugs and because of its widespread uses and multiple brand availability, it is the most commonly prescribed opioid drug in the world. Most prescriptions for codeine are usually for short term purposes such as pain relief after surgery or dental procedures and to treat coughs when over the counter remedies have proven unsuccessful. Common combinations of codeine products include codeine combined with acetaminophen or aspirin for pain relief and guaifenesin or promethazine for coughs.
Codeine Overdose Risks
Codeine should be used at its lowest level to control pain or on an as needed because codeine converts back to morphine when it is metabolized and some people metabolize codeine faster than the standard rates which can put them at higher risk for overdose. According to the National Institute on Drug Abuse,” Codeine and other opioids present a high risk of fatal overdose due to their effect of depressing the central nervous system, which can slow or stop the heart and lungs.”
Dangers of an Increasing Codeine Tolerance
Building a tolerance to drugs like codeine causes people to take more than they intended, and can lead to addiction.
Codeine tolerance can develop quickly and increased dosages of any opioid drugs can lead to physical and/or psychological dependency. Even those who take codeine as prescribed can develop a physical dependency to the drug and suffer withdrawals when they discontinue use.
When a psychological dependency develops, or the drug is used recreationally, increased tolerance can lead to maladaptive behaviors that expose the person to more potent opioids and increase the addiction risk potential.
Increased tolerance to codeine may prompt the person to use other drugs or alcohol to intensify or enhance the medication’s effects and this can cause serious physical and mental health impairments, overdose, or death.
Tolerance to codeine medications poses additional health risks. When the medications are combined with acetaminophen, tolerance may lead the person to use much more than is safe and cause acetaminophen toxicity which can lead to liver failure and death.
Codeine and promethazine cough syrups are frequently abused and some people may consider the cough syrups safe to use combining it with other drugs and alcohol. Because promethazine and codeine decrease breathing and heart rate, increased tolerance or combinations with other substances can be extremely fatal.
History of Codeine -
Opiates have been used throughout history for hundreds of years dating as far back as the Egyptians and the Ancient Chinese and their use of opium. Codeine itself dates back to the 19th century when opium was first used in various proportions along with other drugs to create various forms of opioids. Codeine is found ... 
Dangers of Mixing Codeine and Alcohol -
Codeine, a Schedule II class narcotic opiate, has a wide range of medicinal as well as recreational uses. Like all narcotic-type drugs, codeine carries a fairly high potential for abuse and addiction. As a prescription pain relief medication, codeine appears in combination with other non-opioid pain reliever drugs. When used for recreational purposes, the methods ... 
Why Codeine is a Popular Choice Among Addicts -
Codeine is often found in cough syrup and is less regulated than other opiate-based drugs, making it seem like a safer option. 
Codeine Allergies -
Codeine is a commonly prescribed pain medication that is used to treat mild to moderate acute pain and can also be used to treat cough. Although rare, codeine allergies do occur and can lead to some dangerous symptoms. Typically, a codeine allergy will not occur with the initial or first exposure of the drug but will most ... 
Brand Names -
Codeine is most often combined with other medications and then marketed under certain brand names such as Robitussin AC which contains codeine. There are many branded products on the market that include a combination of codeine and another drug such as Phenylephrine, Pyrilamine, Guaifenesin or Chlorpheniramine. Other combination products may also be found in the medical field ...